Publications by authors named "M M Del Carmen"
Cacalol Acetate as Anticancer Agent: Antiproliferative, Pro-Apoptotic, Cytostatic, and Anti-Migratory Effects.
Curr Issues Mol Biol
August 2024
Cacalol (C), a sesquiterpene isolated from , has demonstrated anti-inflammatory and antioxidant activities. Its cytotoxic, antiproliferative, and pro-apoptotic effects have been previously shown in an in vitro breast cancer model. A derivative, cacalol acetate (CA), shows potential in regulating these processes, which has not been previously reported.
View Article and Find Full Text PDFMonitoring surgical nociception using multisensor physiological models.
Proc Natl Acad Sci U S A
October 2024
Article Synopsis
- * Researchers collected a large dataset from 101 surgeries to analyze nociceptive stimuli and medication use, developing new models that can objectively measure surgical nociception more accurately than existing methods.
- * Their findings suggest that the new models aligned well with known physiological responses to pain, representing progress toward establishing reliable, objective markers for monitoring surgical nociception during operations.
Objective: We conducted a multi-institutional observational study to investigate whether maintenance hormone therapy following primary treatment of low-grade advanced-stage ovarian cancer (LGSOC) is associated with an overall survival advantage.
Methods: We included patients with histologically confirmed stage III or IV LGSOC diagnosed between Jan 1, 2004, and Dec 31, 2019, treated in Commission on Cancer-accredited cancer programs in the US. Patients who received hormone therapy within six months of diagnosis were matched to controls who did not initiate hormone therapy during this timeframe by risk-set propensity score matching.
Article Synopsis
- This study investigates the causes of infections in patients with febrile neutropenia (FN) and evaluates different microbiological testing methods used for diagnosis in a hospital setting.
- Conducted at the Hospital Clinic of Barcelona over two years, it analyzed 4520 tests from 462 FN episodes, revealing a 10% positivity rate and showing that bacterial and viral infections are significant contributors.
- The findings highlight a high rate of documented infections at FN onset, with bacterial infections being common but also emphasize the need for improved management strategies for viral infections, alongside a call for better diagnostic approaches to enhance cost-effectiveness.