Publications by authors named "M M De Pardal"
Male Wistar Rats Chronically Fed with a High-Fat Diet Develop Inflammatory and Ionic Transport Angiotensin-(3-4)-Sensitive Myocardial Lesions but Preserve Echocardiographic Parameters.
Int J Mol Sci
November 2024
The central aim of this study was to investigate whether male Wistar rats chronically fed a high-fat diet (HFD) over 106 days present high levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and Na and Ca transport alterations in the left ventricle, together with dyslipidemia and decreased glucose tolerance, and to investigate the influence of Ang-(3-4). The rats became moderately overweight with an expansion of visceral adiposity. Na-transporting ATPases, sarco-endoplasmic reticulum Ca-ATPase (SERCA2a), and the abundance of Angiotensin II receptors were studied together with lipid and glycemic profiles from plasma and left-ventricle echocardiographic parameters fractional shortening (FS) and ejection fraction (EF).
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- The study investigates the impact of SARS-CoV-2 on the presence and behavior of JC Virus and Norovirus in municipal wastewater, using samples collected in 2020.
- It finds that JC Virus is consistently present in wastewater, indicating transmission through urine, while Norovirus shows changes with different detection rates before and after SARS-CoV-2 appeared.
- The results highlight the inefficiency of the wastewater treatment plant in removing viruses, which raises concerns about tracking viral disease outbreaks based on effluent data.
Evidence synthesis of medical cannabis research: current challenges and opportunities.
Eur Arch Psychiatry Clin Neurosci
November 2024
As a wide group of medicines, the effectiveness and safety of 'medical cannabis' products is likely to vary in relation to product-specific dimensions such as potency, dosage, route of administration, and cannabinoid composition. Systematic reviews can perform a crucial role in analysing and synthesising the outcomes of medical cannabis interventions found in empirical research. We analysed 23 contemporary systematic reviews on the effectiveness and safety of medical cannabis to discern the extent to which this body of work aimed to capture, and ultimately captured, the differing outcomes of medical cannabis products by product-specific dimensions of treatment.
View Article and Find Full Text PDFSeveral invasive species can occupy the same geographic area. Interaction between species depends on several factors, and the results of such interactions can be highly diverse. Asparagopsis armata is a invasive red seaweed whose exudates contain a cocktail of toxic halogenated compounds.
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- The study analyzes how the North Atlantic Oscillation (NAO) affects regional climate, hydrology, and sea surface temperatures, specifically looking at decapod larval communities from 2003 to 2012 in Portugal's Mondego Estuary.
- Research found that sea surface temperature changes significantly influenced the abundance and diversity of key decapod larvae like Carcinus maenas and Diogenes pugilator, especially after notable environmental shifts in 2007.
- Although water temperature was crucial for the larval communities, the rate of Marine Heatwaves (MHW) events did not show a significant impact on these populations, raising concerns about how ongoing climate change may affect these important marine organisms.