Publications by authors named "M M Daadi"
Article Synopsis
- Parkinson's disease (PD) is a chronic and currently incurable illness affecting millions, leading to increased interest in using pluripotent stem cells for cell replacement therapy to restore lost neurons.
- Despite advancements in therapy, challenges persist in effectively connecting these new neurons to the existing brain circuits, but combining cell therapy with physical activity may enhance these connections.
- Exercise, such as treadmill workouts, has been shown to improve motor and cognitive functions in PD patients, enabling them to relearn movements and enhance their neural circuit connections for better overall functioning.
Article Synopsis
- Parkinson's disease (PD) is a progressive neurodegenerative disorder with no cure and candidates for cell replacement therapy are emerging, particularly using induced pluripotent stem cells (iPSCs) to generate dopaminergic neurons.
- Recent research shows that combining physical and cognitive training (PCT) with cell transplantation can significantly improve recovery in a nonhuman primate model, enhancing daily activities and cognitive function six months post-transplant.
- A new, efficient manufacturing process for producing grafted dopamine neurons from iPSCs has been developed, highlighting the potential for better patient outcomes when PCT is integrated with cell therapy.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons which leads to impaired motor and cognitive functions. PD is predominantly an idiopathic disease; however, about 5% of cases are linked to hereditary mutations. The most common mutation in both familial and sporadic PD is the G2019S mutation of .
View Article and Find Full Text PDFParkinson's disease (PD) is primarily idiopathic and a highly heterogenous neurodegenerative disease with patients experiencing a wide array of motor and non-motor symptoms. A major challenge for understanding susceptibility to PD is to determine the genetic and environmental factors that influence the mechanisms underlying the variations in disease-associated traits. The pathological hallmark of PD is the degeneration of dopaminergic neurons in the substantia nigra pars compacta region of the brain and post-mortem Lewy pathology, which leads to the loss of projecting axons innervating the striatum and to impaired motor and cognitive functions.
View Article and Find Full Text PDFThe granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC. Although most cell subtypes defined transcriptomically are conserved, we detected several that exist only in a subset of species as well as substantial species-specific molecular differences across homologous neuronal, glial, and non-neural subtypes.
View Article and Find Full Text PDF