Publications by authors named "M M Crabbe"
Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and toxicities. Here, we develop and employ lipid-based nanoparticles (LNPs) to intratumorally deliver an mRNA mixture encoding the cytokines interleukin (IL)-21 and IL-7 and the immunostimulatory molecule 4-1BB ligand (Triplet LNP). IL-21 synergy with IL-7 and 4-1BBL leads to a profound increase in the frequency of tumor-infiltrating CD8 T cells and their capacity to produce granzyme B and IFN-γ, leading to tumor eradication and the development of long-term immunological memory.
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- - The study investigates the taxonomic and phylogenetic relationships among genera in the Mniaceae family, specifically focusing on the genera Mnium, Plagiomnium, and Pohlia, highlighting controversies in classification.
- - Researchers sequenced the chloroplast genomes of three Plagiomnium species, noting their sizes, structure, GC content, and observed genetic diversity using various analytical methods.
- - Phylogenetic analysis confirmed that the Plagiomnium genus is closely related to Mnium while suggesting that Pohlia is not monophyletic; the findings support the overall monophyly of Mniaceae and a potential revision of Pohlia's classification.
Article Synopsis
- - Human exposure to rare earth elements, particularly lanthanum, cerium, and yttrium, is rising due to their use in various industries, but long-term health effects of mixed exposures remain largely unstudied.
- - A study using LO-2 cell line showed that exposure to LCY mixtures increased oxidative stress and activated the NRF2 pathway, affecting cell cycle progression after 30 to 40 passages.
- - While LCY mixtures did not lead to malignant transformation or tumor growth in mice, they did enhance cell proliferation and migration, suggesting potential health risks that require further investigation.
Introduction: Respiratory syncytial virus (RSV) causes acute respiratory tract infection (ARTI) and reinfects adults throughout life, posing a risk for hospitalization in older adults (>60 years) with frailty and comorbidities.
Methods: To investigate serum and mucosal antibodies for protection against RSV infections, baseline serum samples were compared for RSV-pre- and -post-fusion (F) binding, and RSV-A2 neutralizing IgG antibodies between symptomatic RSV-ARTI ( = 30), non-RSV (RSV negative) ARTI ( = 386), and no ARTI ( = 338). Mucosal RSV-pre-F IgA and IgG levels, as well as serum RSV-G IgG antibodies, were analyzed to determine their association with protection from symptomatic RSV-ARTI in a subset study.