Publications by authors named "M M Christopher"

The perspectives of Yukon's nurses and physicians can determine what might mitigate burnout and strengthen the response to the COVID-19 pandemic and/or future health emergencies. The study was conducted in the Yukon Territory, Canada in two phases: completion of the Copenhagen Burnout Inventory (CBI), and in-depth oral interviews. This paper will discuss the results of the interviews.

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The increasing global prevalence of myopia presents a significant public health concern, and growing evidence has demonstrated that myopia is a major risk factor for the development of open-angle glaucoma. Therefore, timely detection and management of glaucoma in myopic patients are crucial; however, identifying the structural alterations of glaucoma in the optic nerve head (ONH) and retinal tissues of myopic eyes using standard diagnostic tools such as fundus photography, optical coherence tomography (OCT), and OCT angiography (OCTA) presents challenges. Additionally, myopia-related perimetric defects can be confounded with glaucoma-related defects.

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Purpose: To evaluate RETFound, a foundation artificial intelligence model, using a diverse clinical research dataset to assess its accuracy in detecting glaucoma using optic disc photographs. The model's accuracy for glaucoma detection was evaluated across race, age, glaucoma severity, and various training cycles (epochs) and dataset sample sizes.

Design: Evaluation of a diagnostic technology.

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  • Desert tortoise populations are declining due to diseases, predation, and habitat changes, raising questions about the role of minerals and heavy metals in their health.
  • This study analyzed trace minerals and heavy metals in the tissues of sick and dying tortoises to explore their impact on health.
  • Results showed that certain toxic metals were present in all tortoises, with juveniles showing higher levels of lead, tin, and zinc, indicating possible environmental health risks for these animals.
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  • Haploidentical hematopoietic cell transplantation (haplo-HCT) is being utilized more often for blood cancers, but complications such as graft vs. host disease (GvHD) still pose serious risks.
  • A study tested the JAK-1 inhibitor itacitinib alongside standard GvHD preventive care in 42 patients and found it dramatically reduced the severity of complications like cytokine release syndrome (CRS) and instances of acute GvHD.
  • Results showed high overall survival rates (80% at one year) and low rates of both acute and chronic GvHD, indicating that itacitinib is a promising addition to haplo-HCT treatment protocols.
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