Publications by authors named "M M Chien"
Environmental chemicals and toxins are known to impact human health and contribute to cancer developments. Among these, genotoxins induce genetic mutations critical for cancer initiation. In the liver, proliferation serves not only as a compensatory mechanism for tissue repair but also as a potential risk factor for the progression of premalignant lesions.
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- Genetic variants of long noncoding RNAs, specifically SNPs in CDKN2B-AS1, are linked to cancer risk and progression, with a focus on prostate cancer (PCa) in this study.
- Five SNPs were analyzed in a case-control study of 695 PCa patients and 695 healthy individuals, revealing that the rs1333048 variant increases the risk of developing aggressive tumors.
- Higher expression levels of CDKN2B-AS1 were found in individuals with the C allele of rs1333048, which correlated with larger tumors and worse outcomes, suggesting that this variant could influence the progression of prostate cancer.
Hypoxia enhances IL-8 signaling through inhibiting miR-128-3p expression in glioblastomas.
Biochim Biophys Acta Mol Cell Res
December 2024
Glioblastoma multiforme (GBM) is an aggressive type of brain tumor known for its hypoxic microenvironment. Understanding the dysregulated mechanisms in hypoxic GBM is crucial for its effective treatment. Through data mining of The Cancer Genome Atlas (TCGA) with hypoxia enrichment scores and in vitro experiments, miR-128-3p was negatively correlated with hypoxia signaling and the epithelial-mesenchymal transition (EMT).
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- * Researchers studied genetic variants (SNPs) of ADAM9 in 702 Taiwanese PCa patients to see how they affect BCR risk and the progression of the disease.
- * The study found that certain SNPs (particularly rs7006414 and rs6474526) were associated with increased BCR risk and advanced tumor stages, suggesting these genetic variants influence ADAM9 expression and clinicopathological outcomes in PCa patients.
Enhanced weathering of silicate minerals is a promising approach for reducing atmospheric CO levels by increasing the aquatic pH and facilitating CO dissolution. However, the slow and unsustainable dissolution of silicate minerals in natural environments remains a challenge. This study proposed a new CO capture system that uses the combined effect of amino acids and NaCl to promote mineral dissolution, and its characteristics were investigated experimentally.
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