Publications by authors named "M M Cherney"
Background: Renin-independent aldosterone production in normotensive people increases risk for developing hypertension. In parallel, normotensive adrenal glands frequently harbor aldosterone-producing micronodules with pathogenic somatic mutations known to induce primary aldosteronism (PA). A deeper understanding of these phenomena would inform the origins of PA and its role in hypertension pathogenesis.
View Article and Find Full Text PDFBackground: It has been postulated that chronic kidney disease (CKD) is a state of relative 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) insufficiency, resulting in increased cortisol-mediated mineralocorticoid receptor (MR) activation. We hypothesized that relative 11βHSD2 insufficiency manifests across a wide spectrum of progressively declining kidney function, including within the normal range.
Methods: Adult participants were recruited at two academic centers.
Article Synopsis
- Scientists found hormones in elephant and mammoth tusks that show changes related to their reproduction and stress levels over time.
- They used special testing methods to measure hormones in the tusks, and discovered that both the modern elephant and the ancient mammoth had similar mating behaviors called musth.
- This research could help us learn more about how different animals grow and deal with stress, and it could also be useful in areas like medicine and archaeology.