Publications by authors named "M M Carson"
Article Synopsis
- * The researchers found that dark microglia interact with blood vessels and synapses and engage in trogocytosis, meaning they take pieces of pre-synaptic axon terminals.
- * They discovered that dark microglia express specific proteins like CLEC7a, LPL, and TREM2, and that TREM2 is crucial for their function, indicating their important role in synaptic pruning and brain development.
Article Synopsis
- Infections are a major complication in burn patients, particularly among U.S. military personnel who sustained injuries in Iraq and Afghanistan from 2009 to 2014, with 18% of the studied patients developing infections.
- The most common initial infection was pneumonia, occurring within four days post-injury, while those with infections had more severe burns, longer time before surgical treatment, and higher rates of inhalation injury.
- The research indicates that military personnel with burn injuries face significant risks for serious infections, with a notable percentage suffering from multidrug-resistant Gram-negative bacteria and a concerning mortality rate among those with multiple infections.
The liver has a critical role in regulating host metabolism, immunity, detoxification, and homeostasis. Proper liver function is essential for host health, and dysregulation of hepatic signaling pathways can lead to the onset of disease. The Wnt/β-catenin signaling pathway is an important regulator of liver homeostasis and function.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic underscored the challenge of swiftly disseminating research findings to a global audience. Language barriers further exacerbated disparities in access to timely scientific information, particularly for non-English speaking communities. The majority of COVID-19 research was published in English, limiting accessibility for Spanish-speaking populations.
View Article and Find Full Text PDFObesity is an established risk and progression factor for triple-negative breast cancer (TNBC), but preclinical studies to delineate the mechanisms underlying the obesity-TNBC link as well as strategies to break that link are constrained by the lack of tumor models syngeneic to obesity-prone mouse strains. C3(1)/SV40 T-antigen (C3-TAg) transgenic mice on an FVB genetic background develop tumors with molecular and pathologic features that closely resemble human TNBC, but FVB mice are resistant to diet-induced obesity (DIO). Herein, we sought to develop transplantable C3-TAg cell lines syngeneic to C57BL/6 mice, an inbred mouse strain that is sensitive to DIO.
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