Publications by authors named "M M C Chui"
Objectives: Older adults' (ages ≥65) inappropriate over-the-counter medications (OTC) use is prevalent, comprising Drug-Age, Drug-Drug, Drug-Disease, and Drug-Label types. Given that pharmacies sell many OTCs, structurally redesigning pharmacy aisles for improving patient safety (Senior Safe) was conceived to mitigate older adult OTC misuse, using Stop Signs and Behind-the-Counter Signs for high-risk OTCs. This study determined whether Senior Safe reduced high-risk OTCs misuse, while secondarily evaluating misuse changes for all OTCs.
View Article and Find Full Text PDFCell-intrinsic mechanisms of immunogenicity in ovarian cancer (OC) are not well understood. Damaging mutations in the SWI/SNF chromatin remodeling complex, such as (BRG1), are associated with improved response to immune checkpoint blockade; however, the mechanism by which this occurs is unclear. We found that loss in OC models resulted in increased cancer cell-intrinsic immunogenicity, characterized by up-regulation of long-terminal RNA repeats, increased expression of interferon-stimulated genes, and up-regulation of antigen presentation machinery.
View Article and Find Full Text PDFArticle Synopsis
- Older adults (≥65 years) are the biggest users of over-the-counter medications but are at high risk for misuse, leading to potential harmful effects.
- This study recruited 144 older adults from 10 community pharmacies to investigate how they select and plan to use OTC medications when faced with hypothetical symptoms.
- Results showed that 79% of participants exhibited misuse of OTCs, particularly in drug-drug and drug-label categories, with misuse increasing when participants sought to treat worsening symptoms, underlining the urgent need for enhanced OTC safety measures.
In Wisconsin, opioid use disorder (OUD) is highly prevalent among individuals impacted by the criminal justice system. Medications for opioid use disorder (MOUD), including injectable naltrexone, are crucial for treating OUD and especially important for individuals transitioning out of correctional facilities and back into the community. Unfortunately, few formerly incarcerated individuals are able to access MOUD upon community reentry, remaining at high risk of overdose and rearrest.
View Article and Find Full Text PDFArticle Synopsis
- High-grade serous carcinomas (HGSC) primarily originate from fallopian tube precursors, but some arise through a different pathway linked to low-grade serous ovarian neoplasms.
- Research involving whole exome sequencing of low-grade and higher-grade components revealed distinct mutation patterns, with fewer shared mutations between the two, indicating a complex evolutionary process.
- The transformation to HGSC often involves TP53 mutations and is associated with severe cellular abnormalities; however, some tumors with wild-type TP53 show diverse morphological characteristics and less chromosomal instability.