Toxicological Alterations Induced by Subacute Exposure of Cobalt Oxide Nanoparticles in Aged Rats: Behavioral, Biochemical, Molecular, and Histopathological Evidence.

Currently, evidence has pointed out that metal-based nanomaterials may have potentially harmful outcomes in the development of such diseases related to neurodegenerative disorders, oxidative stress, and inflammation. Among them, cobalt oxide nanoparticles (Co3O4-NPs), nano metal-oxides, are widely used in several areas such as industries and as wastewater treatment. Although Co3O4-NPs have a large scale in biological and industrial applications, there is a growing concern to their toxic effect on human health and the environment due to their reduced size and high reactivity, both chemically and biologically.

Polystyrene nanoplastics exacerbate gentamicin-induced nephrotoxicity in adult rat by activating oxidative stress, inflammation and apoptosis pathways.

Nanoplastics (NPs) and pharmaceutical residues are environmental pollutants that can bioaccumulate in the food chain, thus increasing the risk of harmful effects due to concomitant exposure in both humans and animals. However, the impact of such co-exposure on target tissue toxicity and mechanism remains unclear. In this study, we aimed to investigate the effect of combined exposure to widespread polystyrene NP (Ps-NP) contaminant and a widely used antibiotic, gentamicin (GEN) on nephrotoxicity in adult rat.

Pregnancy and Childbearing for Orthopaedic Surgeons: Challenges and Successful Support Initiatives.

While female representation within surgical specialties is increasing, the field of orthopaedic surgery remains male-dominated. Residency, fellowship, and early career coincide with the childbearing years of female surgeons. Given the overlap between these critical career stages and years of childbearing, there has been a rise in articles characterizing the experiences and perceptions around childbearing and its impact on surgeons and their careers.

Gestational exposure to environmental chemical mixtures and cognitive abilities in children: A pooled analysis of two North American birth cohorts.

Background: Gestational exposures to single toxic chemicals have been associated with cognitive deficits in children, but few studies have explored chemical mixtures.

Objectives: To evaluate the associations between gestational chemical biomarker mixtures and cognitive abilities in children from two prospective cohorts.

Methods: This study includes 617 birthing parent-child pairs from the Health Outcomes and Measures of the Environment (HOME) and Maternal-Infant Research on Environmental Chemicals (MIREC) Studies.

Cross-Cultural Translation of the Adolescent Menstrual Bleeding Questionnaire (AMBQ).

Aim: Heavy menstrual bleeding (HMB) affects up to 37% of adolescents. Given the paucity of available tools to assess health-related quality of life (HRQoL) in adolescents with HMB, we developed the adolescent menstrual bleeding questionnaire (aMBQ), a valid and reliable measure of bleeding-related quality of life. The aim of this study was cross-cultural translation and adaptation of the English aMBQ into French to ensure accessibility for more Canadian adolescents who menstruate.