Publications by authors named "M M Bear"
Article Synopsis
- Fragile X syndrome (FXS) is caused by hypermethylation of CGG repeats in the FMR1 gene, resulting in loss of FMRP, which is crucial for normal neuronal function.
- Research has shown that FMRP loss leads to abnormal synaptic activity and hyperexcitability in neurons, but effective treatments have yet to be found due to translation issues from animal models to humans.
- A new high-resolution all-optical electrophysiology platform has been developed to create a sensitive assay that measures FMRP re-expression and healthy neuron restoration, which can be used to identify potential new therapies for FXS.
Article Synopsis
- Amblyopia is a neurodevelopmental visual disorder linked to poor depth perception, typically studied in animals using monocular deprivation during critical visual development stages.
- This study assessed two behavioral tests, the Visual Cliff Assay (VCA) and the Pole Descent Cliff Task (PDCT), to evaluate their effectiveness in detecting binocular issues in mice, especially after manipulating vision.
- Results showed that while both tests were useful, the PDCT was more effective in identifying stereoscopic deficits with fewer mice needed, establishing it as a valuable tool for future studies on binocular vision and amblyopia treatment.
Background: Cancer-related financial hardship is an increasingly recognized concern for patients, families, and caregivers. Many Native American (NA) patients are at increased risk for cancer-related financial hardship due to high prevalence of low income, medical comorbidity, and lack of private health insurance. However, financial hardship screening (FHS) implementation for NA patients with cancer has not been reported.
View Article and Find Full Text PDFBackground: The effectiveness of traditional amblyopia therapies is largely restricted to childhood. However, spontaneous recovery in adulthood is possible following vision loss in the fellow eye due to enucleation, injury, or disease. The twofold purpose of this study was (1) to define the incidence of recovery and (2) to elucidate the clinical features associated with greater amblyopic eye gains.
View Article and Find Full Text PDFBackground: Plaque psoriasis is a chronic dermatologic autoimmune disease that affects adults and children. Roflumilast 0.3% cream is currently the only topical phosphodiesterase 4 inhibitor indicated for the treatment of plaque psoriasis in patients 12 years or older.
View Article and Find Full Text PDF