Biocompatible, porous hydrogels composed of aliphatic polyesters and poly(2-isopropenyl-2-oxazoline). Their application as scaffolds for bone tissue regeneration.

In this study, porous networks were efficiently prepared by crosslinking hydrophilic poly(2-isopropenyl-2-oxazoline) (PiPOx) with dicarboxylic polyesters (HOOC-PLA-COOH or HOOC-PCL-COOH) in the presence of sodium chloride as a water-soluble porogen. Importantly, by using a relatively simple synthetic protocol, the resulting spongy materials were freely formed to the desired size and shape while maintaining stable dimensions. According to the SEM data, the porous 3D structure can be altered by the pore dimensions, which are dependent on the porogen crystal size.

Synthesis and Characterization of Functionalized Polylactides Containing Acetal Units.

New functionalized lactide copolymers containing acetal units were prepared for the first time in a controlled manner that enabled the regulation of the number of reactive groups introduced into the polyester chain. The presence of functional groups in the copolymer backbone provided chemical modification sites, and the nature of the acetal unit affected the material degradability. First, paraformaldehyde was reacted with selected diols containing reactive pendant groups (3-allyloxypropane-1,2-diol and 3-chloropropane-1,2-diol), which was catalyzed by -toluenesulfonic acid, to synthesize new cyclic acetals with different functionalities (allyl- or chloro-).

Covalent segmented polymer networks composed of poly(2-isopropenyl-2-oxazoline) and selected aliphatic polyesters: designing biocompatible amphiphilic materials containing degradable blocks.

To promote facile and efficient synthesis of segmented covalent networks, we developed a cross-linking process with reactive polymeric components in a system without catalysts or side products. To achieve the direct formation of amphiphilic networks, an addition reaction was performed between the polyesters containing carboxyl terminal groups with pendant groups distributed along poly(2-isopropenyl-2-oxazoline) chains. Covalent cross-linking was achieved from predetermined amounts of components dissolved in DMSO at 140 °C.

Polylactide-Based Materials: Synthesis and Biomedical Applications.

Polylactide (PLA) is a biocompatible polyester that can be obtained by polycondensation of lactic acid or the ring-opening polymerization (ROP) of lactide [...

Microfluidic preparation of antimicrobial microparticles composed of l-lactide/1,3-dioxolane (co)polymers loaded with quercetin.

The resistance of microorganisms against commonly used antibiotics is becoming an increasingly important problem in the food and pharmaceutical industries. Therefore, the development of novel bactericidal agents, as well as the design of drug delivery systems based on materials composed of biocompatible and biodegradable building blocks, has attracted increasing attention. To address this challenge, microparticles composed of l-lactide homopolymer and l-lactide/1,3-dioxolane (co)polymers loaded with quercetin (Q) were fabricated by using a microfluidic technique.