Publications by authors named "M M Bagby"
Article Synopsis
- After recovering from acute COVID-19, around 5% of individuals experience prolonged depressive symptoms and cognitive impairments known as COVID-DC, with a focus on the role of astrogliosis in this condition.
- A study was conducted comparing 21 COVID-DC patients and 21 healthy controls, measuring specific indicators of astrogliosis and cognitive/depressive symptoms using PET scans and standardized tests.
- Results indicated higher levels of MAO-B density in key brain areas for COVID-DC patients compared to controls, suggesting potential protective effects of astrogliosis, especially noted since the emergence of the omicron variant.
Importance: Persistent depressive symptoms, often accompanied by cognitive symptoms, commonly occur after COVID-19 illness (hereinafter termed COVID-DC, DC for depressive and/or cognitive symptoms). In patients with COVID-DC, gliosis, an inflammatory change, was suspected, but measurements of gliosis had not been studied in the brain for this condition.
Objective: To determine whether translocator protein total distribution volume (TSPO VT), a marker of gliosis that is quantifiable with positron emission tomography (PET), is elevated in the dorsal putamen, ventral striatum, prefrontal cortex, anterior cingulate cortex, and hippocampus of persons with COVID-DC.
Importance: Monoamine oxidase B (MAO-B) is an important, high-density enzyme in the brain that generates oxidative stress by hydrogen peroxide production, alters mitochondrial function, and metabolizes nonserotonergic monoamines. Recent advances in positron emission tomography radioligand development for MAO-B in humans enable highly quantitative measurement of MAO-B distribution volume (MAO-B VT), an index of MAO-B density. To date, this is the first investigation of MAO-B in the brain of major depressive disorder that evaluates regions beyond the raphe and amygdala.
View Article and Find Full Text PDFMigration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether striatal dopamine function is elevated in immigrants compared to nonimmigrants and the relationship with psychosis.
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