Publications by authors named "M M Alper"

Private medical care has significantly contributed to the advancement of various medical fields. The birth of private IVF groups in the 1990s led to improvements in stimulation protocols, embryo culture, intracytoplasmic sperm injection, vitrification and preimplantation genetic testing. However, infertility is often misunderstood as a disease, leading to low birth rates and a lack of awareness among the general population.

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Regenerative endodontics is a developing field involving the restoration of tooth structure and re-vitality of necrotic pulp. One of the most critical clinical considerations for regenerative endodontic procedures is the disinfection of the root canal system, since infection interferes with regeneration, repair, and stem cell activity. In this study, we aimed to provide the synthesis of injectable biopolymeric tissue scaffolds that can be used in routine clinical and regenerative endodontic treatment procedures using Gelatin methacryloyl (GelMA), and to test the antimicrobial efficacy of Gelatin methacryloyl/Silver nanoparticles (GelMA/AgNP), Gelatin methacryloyl/Hyaluronic acid (GelMA/HYA), and Gelatin methacryloyl/hydroxyapatite (GelMA/HA) composite hydrogels against microorganisms that are often encountered in stubborn infections in endodontic microbiology.

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Objectives: The aim of this study was to investigate the characteristics of de novo malignancies arising in kidney transplant recipients followed in a tertiary hospital in Turkey and to examine the tumors in the head and neck region as a subgroup.

Materials And Methods: Data from kidney transplant recipients treated at our institution between January 2010 and July 2022 were retrospectively analyzed in this single-center study. Data regarding malignancies were noted according to the pathologists' reports.

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Article Synopsis
  • ADAMTS-2 and ADAMTS-3 are enzymes that process collagen precursors, with ADAMTS-2 found in type I collagen-rich tissues and ADAMTS-3 mainly in cartilage and the nervous system.
  • Recent research shows that hypoxia (low oxygen conditions) significantly boosts the expression of both ADAMTS-2 and ADAMTS-3 at the mRNA and protein levels in HUVECs (human umbilical vein endothelial cells).
  • The study found that the hypoxia-inducible factor HIF-1α binds to specific regions in the promoters of these genes, indicating that low oxygen levels enhance their transcriptional activity.
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