A Real-World Comparison of the Safety Profile for Immune Checkpoint Inhibitors in Oncology Patients.

Owing to the growing use of immune checkpoint inhibitors (ICIs) in the treatment of cancer, a wide spectrum of toxicity has arisen among cancer patients. Yet, limited ICI toxicity-related research is currently conducted in our region. This is a retrospective observational study conducted on adult cancer patients who received at least one cycle of ICI single therapy.

Enhancing Clinical Accuracy of Medical Chatbots with Large Language Models.

The rapid advancement of large language models (LLMs) has opened up new possibilities for transforming healthcare practices, patient interactions, and medical report generation. This paper explores the application of LLMs in developing medical chatbots and virtual assistants that prioritize clinical accuracy. We propose a novel multi-turn dialogue model, including adjusting the position of layer normalization to improve training stability and convergence, employing a contextual sliding window reply prediction task to capture fine-grained local context, and developing a local critical information distillation mechanism to extract and emphasize the most relevant information.

Effects of Shading Nets Color on the Internal Environmental Conditions, Light Spectral Distribution, and Strawberry Growth and Yield in Greenhouses.

Greenhouses are used to create the appropriate environment for plant growth. Controlling the level of lighting using shading nets is one of the most commonly used methods for making suitable environmental modifications in greenhouses. The objective of this study was to examine the impact of three colored shading nets (green, black, and beige at shading rates of 50%) on inside air temperature, relative humidity, and spectral distribution of light in a greenhouse, as well as their effect on the growth and yield of strawberry plants.

Real-World Comparison of Health-Related Quality of Life Associated with Use of Immune-Checkpoint Inhibitors in Oncology Patients.

Immune checkpoint inhibitors (ICIs) offer a new treatment approach for cancer, with an improvement in patient survival. However, it remains unclear whether their use impacts the quality of life of treated patients. This study aims to compare the health-related quality of life (HRQoL) of patients treated with different anti-PD-1 and anti-PD-L1 drugs, including several single or combination therapies.

Factors associated with Saudi physicians' utilization of clinical ethics consultation services.

Clinical Ethics Consultation (CEC) aims to resolve ethical dilemmas at the bedside. Through a structured process, CEC allows practitioners and patients to consult ethicists at times of moral conflict or uncertainty. Over the past few decades, CEC has become an invaluable part of healthcare practice.