Publications by authors named "M M Adner"
Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are important causes of morbidity and mortality in critically ill patients. Gastric contents aspiration is one of the most common causes of ALI/ARDS. To date, there are still no specific and effective pharmacological treatments for ALI/ARDS.
View Article and Find Full Text PDFBackground: Microbial infections, particularly those caused by rhinovirus (RV) and respiratory syncytial virus (RSV), are major triggers for asthma exacerbations. These viruses activate toll-like receptors (TLRs), initiating an innate immune response. To better understand microbial-induced asthma exacerbations, animal models that closely mimic human lung characteristics are essential.
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- * The researchers developed a new method called TRISCO, which helps retain RNA signals in cleared organs for better imaging, specifically for whole-brain 3D RNA visualization.
- * TRISCO effectively preserves RNA integrity, ensures uniform labeling, and enhances tissue transparency, making it a powerful tool for detailed transcriptional spatial analysis at the single-cell level across various organs.
Article Synopsis
- - Oxylipins are important signaling lipids formed from fatty acids, playing key roles in inflammatory diseases like asthma, but traditional measurement methods may overlook their spatial distribution in tissues.
- - New mass spectrometry imaging (MSI) techniques, specifically desorption electrospray ionization coupled with triple quadrupole mass spectrometry (DESI-MRM), have improved the sensitivity needed to detect these low-abundance compounds in lung tissues.
- - This research developed a targeted MSI workflow to map five oxylipins in guinea pig lung extracts, discovering distinct spatial distributions that enhance our understanding of lipid metabolism in respiratory tissues.
Background: In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad range of pharmacological properties. Here, we investigated the airway relaxant and anti-inflammatory properties of a novel quinoline (RCD405).
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