Publications by authors named "M M AbdelMohsen"
Purpose Of Review: People with HIV (PWH) experience premature aging and an elevated risk of age-related comorbidities, even with viral suppression through antiretroviral therapy (ART). We examine gastrointestinal disruptions, specifically impaired intestinal barrier integrity and microbial dysbiosis, as contributors to these comorbidities.
Recent Findings: HIV infection compromises the intestinal epithelial barrier, increasing permeability and microbial translocation, which trigger inflammation and cellular stress.
Article Synopsis
- - Viremic non-progressors (VNPs) are a rare group of HIV-1 individuals who maintain normal CD4 T cell counts despite high viral loads, resembling natural hosts of simian immunodeficiency virus, but the reasons for this are not fully understood.
- - A study using single-cell and multiomics methods examined 16 VNPs and 29 HIV+ progressors, revealing genetic factors like CCR5Δ32 heterozygosity and lower CCR5 expression, alongside reduced intestinal disruption and immune responses in VNPs.
- - The research highlights various traits contributing to the immune stability in VNPs, indicating important insights for potential HIV treatment strategies in the future.
Article Synopsis
- The study aimed to explore how consistent and stable liver standardized uptake values (SUV) are across different cancer types while considering normalization methods and blood glucose levels.
- It involved 207 patients with breast, lymphoma, lung, and bone-metastasis cancer, using multiple PET/CT imaging systems after administering a dose of 18F-FDG.
- Findings showed non-significant differences in SUV measurements among the scanners, highlighting the need for careful selection of normalization methods before clinical use, with body surface area normalization potentially offering the best correlation.
Article Synopsis
- The review investigates different biological molecules in bodily fluids that could serve as biomarkers for the HIV post-treatment controller (PTC) phenotype and the timing of viral rebound after stopping antiretroviral therapy (ART).
- It highlights recently discovered viral components and host factors, such as specific antibodies and inflammation markers, that are crucial for understanding the PTC phenotype and predicting viral rebound following ART interruption.
- The authors propose a comprehensive model that incorporates multiple biomarkers to better predict the PTC phenotype and assist in developing new curative treatments for those who do not achieve this phenotype.