Publications by authors named "M M Abdel-Khalek"
Enhancing Photothermal Therapy for Antibiofilm Wound Healing: Insights from Graphene Oxide-Cranberry Nanosheet Loaded Hydrogel in vitro, in silico, and in vivo Evaluation.
Int J Nanomedicine
December 2024
Article Synopsis
- Diabetic foot ulcers are challenging to treat due to bacterial biofilms, oxidative stress, and wet conditions from excess wound exudate.
- A new hydrogel was developed using polyvinyl alcohol and chitosan, incorporating functionalized graphene oxide to enhance its antibacterial qualities.
- This hydrogel showed improved stretchability, effective removal of excess fluid, and significant reductions in inflammation markers, highlighting its potential for better wound healing in diabetic patients.
Designing highly adsorptive materials for wastewater treatment via facile approaches is still challenging. To boost the recovery of heavy metals from wastewater, surface and structure modification are considered a successful route. Herein, we report the design of ZnO nanoparticles by a simple thermal decomposition method followed by grafting Cu nanoparticles (Cu NPs) over the ZnO surface.
View Article and Find Full Text PDFThis review is concerned with chronic wounds, with an emphasis on biofilm and its complicated management process. The basics of antimicrobial photodynamic therapy (PDT) and its underlying mechanisms for microbial eradication are presented. Intrinsically active nanocarriers (polydopamine NPs, chitosan NPs, and polymeric micelles) that can further potentiate the antimicrobial photodynamic effect are discussed.
View Article and Find Full Text PDFRevealing how phenytoin triggers liver damage and the potential protective effects of Balanites Aegyptiaca fruit extracts: Exploring Nrf2/MAPK/ Beclin-1 signaling pathways.
Biomed Pharmacother
September 2023
Phenytoin-induced liver injury (PHT ILII) is a serious condition that may necessitate discontinuation of the drug. This study investigates the mechanisms of PHT ILII and evaluates the protective effects of Balanites Aegyptiaca (BA) fruit extracts on the liver. We focus on the Nrf2/MAPK/NF-κB/Beclin-1 signaling pathways involved in oxidative stress and inflammation from drug-induced liver injury.
View Article and Find Full Text PDFBackground: Careful review of the scientific databases revealed that no stability-indicating analytical method is available for the binary mixture of allopurinol (ALO) and thioctic acid (THA).
Objective: A comprehensive stability-indicating HPLC-DAD procedure has been executed for concurrent analysis of ALO and THA.
Method: Successful chromatographic separation of the cited drugs was reached using a Durashell C18 column (4.