Publications by authors named "M M A Toorop"
Background: Serratia marcescens is known to cause outbreaks in neonatal intensive care units (NICUs). Traditionally epidemiological data, antimicrobial resistance patterns and epidemiological typing have been used to guide infection prevention methods. Whole-genome sequencing (WGS) applications such as core-genome multi-locus sequence typing (cgMLST) applied during an outbreak would potentially yield more information.
View Article and Find Full Text PDFThe recently observed increase in invasive infections causes concern in Europe. However, conventional molecular typing methods lack discriminatory power to aid investigations of outbreaks caused by . Therefore, there is an urgent need for high-resolution molecular typing methods to assess genetic relatedness between isolates.
View Article and Find Full Text PDFImportance: The temporal trend in adverse events regarding stroke prevention for nonvalvular atrial fibrillation (NVAF) in the direct oral anticoagulant (DOAC) era was rarely investigated comprehensively, especially taking into account potential changes in patient characteristics and anticoagulation treatment.
Objective: To investigate time trends in patient characteristics, anticoagulation treatment, and prognosis of patients with incident NVAF in the Netherlands.
Design, Setting, And Participants: This retrospective cohort study assessed patients with incident NVAF initially recognized within a hospitalization between 2014 and 2018, using data from Statistics Netherlands.
Article Synopsis
- Non-valvular atrial fibrillation (NVAF) patients are often recommended to switch from vitamin K antagonists (VKAs) to direct oral anticoagulants (DOACs) when their time in therapeutic range (TTR) is low.
- A study analyzed 3,696 NVAF patients who switched from VKAs to DOACs, finding that those with a pre-switch TTR of 45% or lower had a 14% non-persistence rate within a year compared to 9.8% for those with higher TTRs.
- The results suggest that a low pre-switch TTR is linked to a higher likelihood of not adhering to DOAC treatment, indicating a need for careful monitoring and
Article Synopsis
- Direct oral anticoagulants (DOACs) are often used without the need for concentration monitoring, but their stability and variability between and within patients has not been extensively researched.
- In a study involving 152 patients switching from vitamin K antagonists to DOACs, researchers found significant inter-individual variability in drug concentrations, with a larger variability in trough values compared to peak values.
- The study concluded that previous VKA dosage and kidney function (creatinine clearance) impacted DOAC levels, highlighting the need for further research into optimal dosing to minimize bleeding and thrombosis risks.