Publications by authors named "M Lynn Shay"
Article Synopsis
- - M2D2 is a two-stage machine learning pipeline that helps discover effective antimicrobial drug combinations, aiming to tackle drug resistance without the need for costly omics data.
- - It enhances the accuracy of identifying drug targets by using both experimental and computational methods, and provides insights into how different drugs interact with each other.
- - The framework was validated with experiments involving 946 combinations of approved drugs and antibiotics, revealing promising synergies, including a notable combination of a cerebrovascular drug and penicillin, while also confirming these findings through genome-wide CRISPR screens.
Article Synopsis
- Antibody-mediated inhibition of ADAMTS-13, a protein critical for blood clotting, leads to immune thrombotic thrombocytopenic purpura (iTTP), but the impact of multiple antibodies on this process is not fully understood.
- The study examines how different antibodies interact with ADAMTS-13 and finds that while both stimulatory and inhibitory antibodies can bind simultaneously, the inhibition prevails when both are present.
- Results suggest that these antibodies modify ADAMTS-13's catalytic activity through allosteric changes, indicating potential pathways for developing new diagnostic and therapeutic strategies for managing iTTP.
Article Synopsis
- Turbulence and magnetic reconnection are important nonlinear plasma phenomena that significantly affect energy transport in space and astrophysical plasmas.
- Recent high-resolution, multi-spacecraft observations have improved our understanding of their complex interactions, revealing how turbulence generates current sheets that can undergo reconnection.
- This paper reviews current knowledge on these interactions in collisionless plasmas, particularly in Earth's magnetosphere, highlighting findings from NASA's missions in key areas like the magnetosheath and magnetotail.
Objective: Utilizing biological scaffolds for cartilage tissue engineering is a promising tool for improving auricular reconstruction. Decellularized auricular scaffolds provide a means of regenerating cartilage for in vivo implantation, but identifying the ideal regenerative mix remains challenging.
Methods: Human cadaver auricular cartilage was decellularized and recellularized with either auricular chondrocytes alone, auricular chondrocytes with adipose-derived stem cells, or both cells with platelet-rich plasma.
IntelliSep by Cytovale has received United States (U.S.) Food and Drug Administration (FDA) approval as a sepsis biomarker test.
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