Publications by authors named "M Luiza de Souza-Galvao"
Background: People with pulmonary tuberculosis (PTB) are contagious, particularly to their household contacts. Their infectivity has been associated with the bacterial load in sputum samples. This study investigated if the bacterial load in sputum samples as quantified by Xpert MTB/RIF and Xpert Ultra is correlated with the extent that latent tuberculosis infection (LTBI) occurred in household contacts of people with PTB.
View Article and Find Full Text PDFPurpose: This study investigates the potential of inflammatory parameters (IP), symptoms, and patient-related outcome measurements as biomarkers of severity and their ability to predict tuberculosis (TB) evolution.
Methods: People with TB were included prospectively in the Stage-TB study conducted at five clinical sites in Barcelona (Spain) between April 2018 and December 2021. Data on demographics, epidemiology, clinical features, microbiology, and Sanit George Respiratory Questionnaire (SGRQ) and Kessler-10 as Health-Related Quality of Life (HRQoL) were collected at three time points during treatment.
Article Synopsis
- Diagnosing infections caused by non-tuberculous mycobacteria (NTM) is complex, and this study evaluates a new immunological assay (NTM-IGRA) using specific antigens from glycopeptidolipids (GPLs).
- The study tested this assay on 99 pediatric patients, including those with confirmed NTM infections and controls without lymphadenitis, finding that samples from NTM-confirmed patients reacted significantly more to GPLs than those with unknown infections or other causes.
- Results suggest that the NTM-IGRA could effectively identify NTM infections in children, potentially improving diagnosis and reducing misdiagnosis and unnecessary treatments.
Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort.
Eur Respir J
November 2023
Article Synopsis
- This global study investigates the long-term outcomes of patients with tuberculosis (TB) and COVID-19, highlighting a lack of prior longitudinal data on this combined condition.
- Data was collected from 788 patients across 31 countries from March 2020 to September 2022, showing a mortality rate of 10.8% during the study period.
- Key factors influencing mortality included older age, HIV infection, and the need for invasive ventilation, with patients suffering from both diseases experiencing significantly lower survival rates compared to those with only one of the diseases.