Publications by authors named "M Luisa Villalobos"
Background: Advanced lung cancer typifies the challenges of participatory decision-making in oncology. With a limited prognosis for survival, the increasingly numerous and complex treatment options must continually be weighed against issues of fragility, quality of life, and the end of life.
Methods: This randomized, controlled trial, carried out on 138 patients, concerned the use of a decision aid combined with decision coaching, versus standard care.
Article Synopsis
- * From a survey of 1,368 US parents, 10.1% reported their child has severe autism, with these children more likely to have intellectual disabilities and significant language delays compared to those with mild/moderate autism.
- * Children labeled as severe/autistic face more behavioral challenges and caregiver stress, indicating they may require additional therapy and support to improve their well-being and access to healthcare.
Background And Purpose: Despite that incorporating antiangiogenic in combination with immune-checkpoint inhibitors as the standard first-line treatment for advanced clear cell renal cell cancer (ccRCC) yields promising outcomes, these regimens often lead to significant toxicity. However, a subgroup of patients has shown responsiveness to VEGFR tyrosine-kinase inhibitors (TKIs) in monotherapy, leading to the question of whether employing combination therapies can significantly enhance overall survival in all patients over monotherapy. Thus, we aim to identify gene expression signatures that can predict TKI response within subpopulations that might benefit from single-agent therapies, to minimize unnecessary exposure to combination therapies and their associated toxicities, as well as to discover new potential therapeutic targets to improve ccRCC treatment.
View Article and Find Full Text PDFDuring the rapid development of COVID-19 vaccines, concerns emerged about potential adverse effects on menstrual health. This study examines the association between COVID-19 vaccination-considering the number of doses and vaccine type-and menstrual disorders, specifically heavy menstrual bleeding (HMB) and amenorrhea (AM). Utilizing electronic health records from the Sistema d'Informació per al Desenvolupament de la Investigació en Atenció Primària (SIDIAP) database in Catalonia, Spain, the retrospective cohort included 1,172,621 vaccinated women aged 12-55 with no prior menstrual disorders observed from 27 December 2020 to 30 June 2023.
View Article and Find Full Text PDFArticle Synopsis
- * A case study is presented involving a 22-year-old DMD patient undergoing surgery for bone fractures, where a unique anesthetic approach combining total intravenous anesthesia and regional anesthesia was utilized.
- * The text discusses the challenges of perioperative care in DMD, highlights specific anesthetic concerns, and reviews previous reports on the use of regional anesthesia in patients with this condition.