A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.

Interstitial lung disease (ILD) consists of a group of immune-mediated disorders that can cause inflammation and progressive fibrosis of the lungs, representing an area of unmet medical need given the lack of disease-modifying therapies and toxicities associated with current treatment options. Tissue-specific splice variants (SVs) of human aminoacyl-tRNA synthetases (aaRSs) are catalytic nulls thought to confer regulatory functions. One example from human histidyl-tRNA synthetase (HARS), termed HARS because the splicing event resulted in a protein encompassing the WHEP-TRS domain of HARS (a structurally conserved domain found in multiple aaRSs), is enriched in human lung and up-regulated by inflammatory cytokines in lung and immune cells.

The Impact of Visual and Haptic Feedback on Keyboard Typing in Immersive Virtual Environments.

Typing with a keyboard is a common task in content production in the workplace. For simulation purposes in VR environments, it is important for users to perform this task accurately, with minimal performance loss, and without distraction. One common approach is using mid-air typing on virtual keyboards.

Fenestrated Endovascular Aortic Aneurysm Repair Is Associated With Increased Sac Regression On Post-operative Volumetric Analysis Compared To EVAR Sac Regression Volumetrics after FEVAR.

Objectives: Endovascular aortic aneurysm repair (EVAR) is utilized to treat abdominal aortic aneurysms, while patients with short infrarenal necks can undergo fenestrated EVAR (FEVAR). Previous studies have demonstrated decreased aortic neck dilation for FEVAR compared to EVAR. Sac regression is a marker of success after EVAR, however, little is known regarding changes in sac volumetrics.

Extension of the visibility concept for EEG signal processing.

. Visibility is an intrinsic property of any network of sensors that describes the regions in which its measurement sensitivity is concentrated. Initially introduced to describe the global spatial sensitivity of air pollution monitoring networks, we propose to extend the concept of visibility to characterize the detection capabilities of electroencephalography (EEG) systems utilized to measure brain electrical activity.

Generation of Functional Brain Region-Specific Neural Spheroids for High Throughput Screening.

Therapeutic development and research in the neurodegenerative disease field encounters many challenges such as availability of reproducible and scalable cellular model systems that are biologically, physiologically, and pharmacologically relevant. These cellular models must be informative of cellular mechanisms of diseases and predictive for therapeutics efficacy and toxicity testing during drug discovery and development. Neural spheroids fill the gap of cellular models of the brain that are functional, versatile in neural cell type composition, robust, and scalable for high-throughput screening (HTS).