Publications by authors named "M Luisa Mansego"
Article Synopsis
- Epigenetic mechanisms, influenced by diet, may explain why some individuals are more susceptible to diseases, prompting a study on their relationship with DNA methylation (DNAm) and metabolic health in Spain.
- The study involved 337 participants and assessed diet quality using a food frequency questionnaire along with established dietary scores related to plant-based diets and processed food consumption.
- Findings indicated significant correlations between certain nutrients and specific DNA sites, with dietary impacts on DNAm linked to obesity and key metabolic risk factors, highlighting how diet quality can predict metabolic health outcomes.
Age-related neurodegenerative diseases involving amyloid aggregation remain one of the biggest challenges of modern medicine. Alterations in the gastrointestinal microbiome play an active role in the aetiology of neurological disorders. Here, we dissect the amyloidogenic properties of biofilm-associated proteins (BAPs) of the gut microbiota and their implications for synucleinopathies.
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- Osteoporosis and its complications are believed to stem from bone aging, environmental influences, and genetic factors, with oxidative stress playing a critical role in age-related bone issues.
- This study analyzed genetic variants related to oxidative stress in 221 patients with osteoporosis and 354 controls over a 12-14 year period.
- Key findings indicated that the SNP rs4077561 in the TXNRD1 gene significantly increases fracture risk, alongside other SNPs in related genes like M6PR and GPX6, highlighting the importance of genetic predisposition in osteoporosis.
The aim of the present investigation was to identify putative miRNAs involved in the response to weight loss. Reverse-transcribed RNA isolated from white blood cells (WBCs) of a subpopulation from the Reduction of the Metabolic Syndrome in Navarra-Spain (RESMENA-S) study (low-responders (LR) and high-responders (HR)) was hybridized in a gene expression microarray. Moreover, miRNAs were sequenced by miRNA-Seq.
View Article and Find Full Text PDFEpigenetic signatures such as DNA methylation may be associated with specific obesity traits in different tissues. The onset and development of some obesity-related complications are often linked to visceral fat accumulation. The aim of this study was to explore DNA methylation levels in peripheral white blood cells to identify epigenetic methylation marks associated with waist circumference (WC).
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