Anaphylaxis management: knowledge of Brazilian pediatricians.

Objective: To verify the level of knowledge of Brazilian pediatricians about anaphylaxis, identifying sociodemographic and educational characteristics of the professional which contribute to the adequate management of this clinical disorder.

Methods: A survey was carried out on the management of anaphylaxis using a questionnaire prepared and distributed by email to pediatricians in different states in Brazil. The level of knowledge about anaphylaxis was classified as: satisfactory; unsatisfactory; more than satisfactory; ideal, according to evaluation criteria adopted for the statements of clinical cases that addressed the drug of choice, route of administration, positioning of the patient with anaphylaxis and recognition of the clinical case with differential diagnosis.

Downregulated Regucalcin Expression Induces a Cancer-like Phenotype in Non-Neoplastic Prostate Cells and Augments the Aggressiveness of Prostate Cancer Cells: Interplay with the G Protein-Coupled Oestrogen Receptor?

Background/objectives: Regucalcin (RGN) is a calcium-binding protein and an oestrogen target gene, which has been shown to play essential roles beyond calcium homeostasis. Decreased RGN expression was identified in several cancers, including prostate cancer (PCa). However, it is unknown if the loss of RGN is a cause or a consequence of malignancy.

Spontaneous Tumor Lysis Syndrome in a Thoracic Burkitt Lymphoma: A Case Report.

Burkitt lymphoma has a high proliferation rate and a significant risk of tumor lysis syndrome. Risk stratification and early identification are imperative since it is an oncological emergency. We report the case of a 20-year-old woman, without relevant past medical history, admitted to the Emergency Department with a three-week history of fatigue, chest discomfort, productive cough, night sweats, myalgia, odynophagia, and holocranial headache.

Association between omega-3 index and depersonalization among healthcare workers in a university hospital: a cross-sectional study.

Introduction: Burnout harms workers physical and mental health due to induced brain changes, autonomous nervous system and hypothalamus-pituitary-adrenal axis excessive activation. Although several correlations and risk factors have been identified, the research around burnout biological correlates remains underdeveloped. The omega-3 index has been proposed in mental health as a contributor to identify high risk patients and monitor disease advancements but the evidence on its relationship with burnout is limited.

Effect of Diosgenin in Suppressing Viability and Promoting Apoptosis of Human Prostate Cancer Cells: An Interplay with the G Protein-Coupled Oestrogen Receptor?

Diosgenin is a phytosteroid sapogenin with reported antitumoral activity. Despite the evidence indicating a lower incidence of prostate cancer (PCa) associated with a higher consumption of phytosteroids and the beneficial role of these compounds, only a few studies have investigated the effects of diosgenin in PCa, and its mechanisms of action remain to be disclosed. The present study investigated the effect of diosgenin in modulating PCa cell fate and glycolytic metabolism and explored its potential interplay with G protein-coupled oestrogen receptor (GPER).