Differential expression of vascular endothelial growth factor-a isoforms in neovascular age-related macular degeneration.

Purpose: To investigate the role of vascular endothelial growth factor-A (VEGF-A) isoforms in neovascular age-related macular degeneration.

Methods: Choroidal neovascular membranes (CNV) were excised in 24 patients, 8 of them underwent previous photodynamic therapy. All procedures were performed before anti-VEGF therapies were implemented in Germany.

Comparing the effects of two different irrigation solutions on an isolated perfused vertebrate retina.

Purpose: To compare the effect of a taurine-containing intraocular irrigation solution (PuriProtect TM) to a standard irrigation solution (BSS TM) we evaluated the retinal function using an electroretinogram (ERG) and analyzed the survival of retinal ganglion cells on isolated whole mount retinas.

Materials And Methods: During ERG recordings, each irrigation solution was superfused for 45 min with the relevant irrigation solution. To investigate the effects on photoreceptor function, 1 m M asparate was added to obtain a-waves.

The effects of the intraocular dye brilliant blue G (BBG) mixed with varying concentrations of glucose on retinal function in an isolated perfused vertebrate retina.

Background: During vitreoretinal surgery, vital dyes such as brilliant blue G (BBG) are used to visualize anatomical structures. By adding glucose to a concentration of 5%, many surgeons try to achieve a dye mixture heavier than water to facilitate staining of the ILM without preceding fluid-air exchange. However, the intraocular use of high glucose concentrations is critical.

Papillary capillary activation in Terson syndrome.

We report the immunopathology and histopathology of a patient with Terson syndrome. The design was an observational case-report. Histopathology and immunohistochemical staining for endoglin (CD105) of an eye from a patient with subarachnoid haemorrhage and Terson syndrome was performed.

Systematic evaluation of ICG and trypan blue related effects on ARPE-19 cells in vitro.

The aim of our study was a systematic analysis of the impact of variable parameters on indocyanine green (ICG) and trypan blue (TB) related cytotoxicity on human RPE cells. ARPE-19 cells were incubated with ICG (5.0-0.