Publications by authors named "M Lueder"
Article Synopsis
- Pediatric low-grade gliomas (pLGGs) show varying treatment responses and poor outcomes when complete tumor removal isn't possible, making early treatment prediction important.
- A radiogenomic analysis combining MRI and RNA sequencing reveals three immune clusters in pLGGs, with one cluster having higher immune activity but worse prognosis, suggesting they might benefit from immunotherapy.
- A developed radiomic signature accurately predicts these immune profiles and progression-free survival, identifying high-risk patients for potential targeted therapies.
Background: Gliomas are a major cause of cancer-related death among children, adolescents, and young adults (age 0-40 years). Primary mismatch repair deficiency (MMRD) is a pan-cancer mechanism with unique biology and therapeutic opportunities. We aimed to determine the extent and impact of primary MMRD in gliomas among children, adolescents, and young adults.
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- The Open Pediatric Cancer (OpenPedCan) Project builds upon the earlier Open Pediatric Brain Tumor Atlas, analyzing data from over 6,000 pediatric cancer patients and providing a vast multi-omic dataset from various tumor types.
- The project integrates multiple genomic and proteomic data types, allowing researchers to access harmonized data through platforms like GitHub, CAVATICA, and AWS.
- OpenPedCan enhances molecular subtyping of tumors by incorporating methylation information, facilitating research that supports more accurate diagnosis and treatment strategies in pediatric cancer.
Unlabelled: The trace-element and isotope geochemistry of rutile are robust tools to determine metamorphic temperatures, age, and host-/source lithologies. The use of rutile as single grain indicator for pressure, temperature, time and composition (P-T-t-X) of the host rock, which is vital in the use of detrital rutile to trace plate-tectonic regimes throughout Earth's history, requires the identification of a pressure dependent trace element in rutile. We investigate the pressure dependence of hydrogen in rutile using polarized in-situ Fourier Transform Infrared (FTIR) spectroscopy.
View Article and Find Full Text PDFPurpose: The PNOC001 phase II single-arm trial sought to estimate progression-free survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low-grade glioma (pLGG) on the basis of phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway activation as measured by phosphorylated-ribosomal protein S6 and to identify prognostic and predictive biomarkers.
Patients And Methods: Patients, age 3-21 years, with progressive/recurrent pLGG received everolimus orally, 5 mg/m once daily. Frequency of driver gene alterations was compared among independent pLGG cohorts of newly diagnosed and progressive/recurrent patients.