Publications by authors named "M Luczak"
Article Synopsis
- The study focuses on how certain blood morphology parameters can predict postoperative mortality for patients undergoing coronary artery bypass grafting (CABG) and off-pump CABG (OPCAB).
- A total of 520 patients were evaluated, revealing that abnormal lymphocyte counts notably increased the risk of death during one and five-year follow-ups, while other factors like red blood cell distribution width (RDW-SD), neutrocyte-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were also linked to heightened mortality rates.
- The findings suggest that monitoring these blood parameters may help assess the risk of early and late mortality in patients undergoing these surgical procedures
Formaldehyde (FA) is a human carcinogen with ubiquitous environmental exposures and significant endogenous formation. Genotoxic activity of FA stems from its reactivity with DNA-NH groups. Histone lysines are another source of aldehyde-reactive amino groups in chromatin, however, chromatin/histone damage responses to FA and their biological significance are poorly understood.
View Article and Find Full Text PDFSensitive Detection of Histones and γ-H2AX by Immunoblotting: Problems and Solutions.
Chem Res Toxicol
September 2024
Histones and their posttranslational modifications (PTMs) are critical regulators of gene expression. Differentiation, environmental stressors, xenobiotics, and major human diseases cause significant changes in histone variants and PTMs. Western blotting is the mainstay methodology for detection of histones and their PTMs in the majority of studies.
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