Limited impact of colistin resistance on mortality of intensive care patients with carbapenem-resistant bacteraemia.

Background: Increasing incidence of carbapenem-resistant Gram-negative bacteraemia (CR-GNB) has triggered increased use of polymyxins, likely fuelling the emergence and spread of colistin resistance.

Aim: To estimate the excess clinical burden of colistin resistance in intensive care patients with CR-GNB.

Methods: A cohort of patients with CR-GNB during their stay in the intensive care unit (ICU) of a university hospital in Greece over a 4-year period (2020-2023) was constructed.