The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs.

Introduction: The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen (O₂) supply during acute normovolemic anemia has not been investigated so far.

Methods: Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration (Hbcrit).

Neuromuscular blockade with rocuronium bromide increases the tolerance of acute normovolemic anemia in anesthetized pigs.

Background: The patient's individual anemia tolerance is pivotal when blood transfusions become necessary, but are not feasible for some reason. To date, the effects of neuromuscular blockade (NMB) on anemia tolerance have not been investigated.

Methods: 14 anesthetized and mechanically ventilated pigs were randomly assigned to the Roc group (3.

Improved short-term survival with polyethylene glycol modified hemoglobin liposomes in critical normovolemic anemia.

Objective: To investigate the efficacy of a polyethylene glycol (PEG) modified formulation of liposome-encapsulated hemoglobin (LEH) as an oxygen-carrying blood substitute in the treatment of critical normovolemic anemia.

Design And Setting: Prospective, controlled, randomized experimental study in a university research facility.

Subjects: 14 anesthetized and mechanically ventilated beagle dogs.