Publications by authors named "M Lorenzo de Arriba"
Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a genodermatosis characterized by severe cutaneous and mucosal fragility, and frequently complicated by multifactorial chronic anemia that responds poorly to conventional therapies. This cross-sectional study investigates the factors contributing to anemia in RDEB by analyzing a representative cohort, that was stratified by disease severity, anemia and iron status, to examine their hematological parameters, cytokine profile and erythropoietin (EPO)-erythroferrone (ERFE)-hepcidin axis. Anemia was present in 50% of the cohort.
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- - The study investigated electrical coupling in pelvic floor muscles (PFM) of 24 chronic pelvic pain (CPP) patients before and after botulinum neurotoxin type A (BoNT/A) treatment, comparing results to 24 healthy women.
- - Researchers analyzed surface electromyographic (sEMG) signals to assess both two-sided (left and right) and one-sided (same side) coupling of the PFMs, measuring changes in amplitude and phase before and after treatment.
- - Findings revealed that while two-sided coupling was similar for both groups before treatment, one-sided coupling in the most painful side of CPP patients remained disrupted, indicating potential ongoing effects of pain and treatment on neuromotor control and muscle function.
Many common skin diseases are associated with changes in the microbiota. This applies for the commensal yeast Malassezia, which is linked to a wide range of skin disorders ranging from mild dandruff to severe seborrheic and atopic dermatitis, all of which have a detrimental impact on the individuals' quality of life. While antifungal medications offer relief in many cases, the challenges of disease recurrence and the emergence of resistance to the limited range of available antifungal drugs poses a pressing need for innovative therapeutic options.
View Article and Find Full Text PDFBackground: GOIZ ZAINDU ("caring early" in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) methodology to the Basque population and evaluate the feasibility and adherence to a FINGER-like multidomain intervention program. Additional aims included the assessment of efficacy on cognition and data collection to design a large efficacy trial.
Method: GOIZ ZAINDU is a 1-year, randomized, controlled trial of a multidomain intervention in persons aged 60+ years, with Cardiovascular Risk Factors, Aging and Dementia (CAIDE) risk score ≥ 6, no diagnosis of dementia, and below-than-expected performance in at least one of three cognitive screening tests.