Publications by authors named "M Lonardoni"
Leishmaniasis is a neglected disease that affects millions of people worldwide, and special attention should be given to treatment because the available drugs have limitations, which can lead to low therapeutic adherence and parasitic resistance. This study evaluated the activity of the bioactive naphthoquinones, lapachol and β-lapachone, against Leishmania amazonensis. The cell alterations were evaluated in vitro on promastigote and amastigote forms.
View Article and Find Full Text PDFLow values of the ratio of plasmatic soluble blocking factor FMS-like tyrosine Kinase 1 and placental growth factor (sFlt-1/PlGF) are required for an adequate placental angiogenesis and function. It has been shown that patients affected by gestational diabetes (GD) and patients with pneumonia from SARS-CoV-2 are characterized by an increased sFlt-1/PlGF ratio. The aim of the present study was to evaluate the sFlt-1-PlGF ratio in pregnancies complicated by COVID-19 and GD.
View Article and Find Full Text PDFArticle Synopsis
- The Phytolaccaceae family, part of the Caryophyllales order, includes plants used in traditional medicine, prompting a study to explore their potential antimicrobial properties.
- The research followed the PRISMA protocol and reviewed 95 publications, narrowing down to 22 articles that reported on the antimicrobial activities of various extracts from Phytolaccaceae plants, including antibacterial, antifungal, and antiviral effects.
- The study highlights the need for higher-quality research to confirm the clinical effectiveness of these plants and their potential as sources for new herbal medicines, while also emphasizing the importance of preserving these species for biodiversity.
A standardized intraperitoneal Glucantime™ for experimental treatment of cutaneous leishmaniasis caused by Leishmania amazonensis in BALB/c mice.
Exp Parasitol
May 2022
Glucantime™ is the pentavalent antimony (Sb) recommended as the first choice for treating cutaneous leishmaniasis (CL). It has been used as treatment control in animal studies to investigate new anti-Leishmania compounds. However, these studies have a range of Glucantime™ doses, different treatment times and routes of administration, and differing results.
View Article and Find Full Text PDFThe anti-Leishmania potential of bioactive compounds derived from naphthoquinones and their possible applications. A systematic review of animal studies.
Parasitol Res
May 2022
Leishmaniasis affects millions of people worldwide, and available treatments have severe limitations. Natural and derivative products are significant sources of innovative therapeutic agents. Naphthoquinones are natural or synthetic chemical compounds with broad biological activity.
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