Publications by authors named "M Loftus"
Background: Metered dose inhalers (MDIs) are important devices for delivering inhaled medications; however, they have an outsized carbon footprint due to their propellant gas. Many short-acting beta-agonist inhalers contain HFA-134a which has a global warming potential >1000 fold higher than carbon dioxide. We aimed to determine the practices around MDI use and disposal within Australia's major lung function testing laboratories and identify the actions that most influence the carbon footprint of bronchodilator responsiveness (BDR) testing.
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- * It achieves a high level of completeness, closing 92% of previous assembly gaps and fully assembling complex regions, including 1,852 complex structural variants and 1,246 human centromeres.
- * The findings lead to significant improvements in genotyping accuracy and enable the detection of over 26,000 structural variants per sample, enhancing the potential for future disease association research.
Article Synopsis
- The study presents detailed genomes of six ape species, achieving high accuracy and complete sequencing of all their chromosomes.
- It addresses complex genomic regions, leading to enhanced understanding of evolutionary relationships among these species.
- The findings will serve as a crucial resource for future research on human evolution and our closest ape relatives.
Unlabelled: The fate of herpesvirus genomes following entry into different cell types is thought to regulate the outcome of infection. For the Herpes simplex virus 1 (HSV-1), latent infection of neurons is characterized by association with repressive heterochromatin marked with Polycomb silencing-associated lysine 27 methylation on histone H3 (H3K27me). However, whether H3K27 methylation plays a role in repressing lytic gene expression in non-neuronal cells is unclear.
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- Scientists are looking for better ways to detect pancreatic cancer early so it can be treated more effectively.
- They studied blood samples from 426 patients to find different markers that could indicate pancreatic cancer compared to other conditions.
- Results showed that a mix of certain protein markers and DNA changes in the blood can help identify early-stage pancreatic cancer better than just using one marker alone.