Protective Efficacy of Decreasing Antigen Doses of a Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model.

Background/objective: , the cause of ovine enzootic abortion, is a zoonotic bacterial pathogen and one of the most infectious causes of foetal death in sheep worldwide. Although the disease can be controlled using commercial inactivated and live whole-organism vaccines, there are issues with both, particularly concerning efficacy and safety. Recently, we have described the development of a new COMC (chlamydial outer membrane complex) vaccine based on a detergent-extracted outer membrane protein preparation of the pathogen, which can be delivered in a single inoculation and is both efficacious and safe.

Expansion of a conserved architecture drives the evolution of the primate visual cortex.

Human brain evolution is marked by a disproportionate expansion of cortical regions associated with advanced perceptual and cognitive functions. While this expansion is often attributed to the emergence of novel specialized brain areas, modifications to evolutionarily conserved cortical regions also have been linked to species-specific behaviors. Distinguishing between these two evolutionary outcomes has been limited by the ability to make direct comparisons between species.

The effect of caricaturing on the esthetic appeal of familiar faces, and its relation to simple proportion judgments.

It has been suggested that caricaturing enhances esthetic appeal, by making an image more strongly stimulate those areas of the brain encoding the subject's distinctive features than does the subject itself. However, some experimental work suggests that people prefer faces with proportions closer to average, or closer to a particular template. It might be that familiarity with the face is important if caricaturing is to increase the esthetic appeal of a likeness.

Face cells encode object parts more than facial configuration of illusory faces.

Humans perceive illusory faces in everyday objects with a face-like configuration, an illusion known as face pareidolia. Face-selective regions in humans and monkeys, believed to underlie face perception, have been shown to respond to face pareidolia images. Here, we investigated whether pareidolia selectivity in macaque inferotemporal cortex is explained by the face-like configuration that drives the human perception of illusory faces.