Publications by authors named "M Lisker Melman"
Ethnomedical knowledge of plants used in alternative medicine to treat hemorrhoidal diseases in Lubumbashi, Haut-Katanga province, Southern Democratic Republic of Congo.
BMC Complement Med Ther
October 2024
Article Synopsis
- * Data was collected from 1,604 respondents, including households, herbalists, and traditional healers, revealing 100 plant taxa associated with hemorrhoid treatment, with Phyllanthus amarus being the most frequently cited.
- * Results highlight that many of these plants also serve other medical purposes, and the study identifies 14 plants newly recognized for hemorrhoid treatment, showing the rich diversity of traditional medicine in the region.
SCL and LMO1 were both discovered by virtue of their activation by chromosomaltranslocation in patients with T-cell acute lymphoblastic leukemia (T-ALL). Overexpression of SCL and LMO1 in the thymus of transgenic mice leads to T-ALL at a young age. scid (severe combined immunodeficient) mice are unable to efficiently recombine antigen receptor genes and consequently display a developmental block at the CD4-CD8- to CD4+CD8+ transition.
View Article and Find Full Text PDFWe have established a panel of nine immortal cell lines from T cell malignancies which arose in mice transgenic for the SCL and LMO1 genes. Cells from the primary malignancies initially grew very slowly in vitro, loosely attached to a stromal layer, before gaining the ability to proliferate independently. Upon gaining the ability to proliferate in the absence of a stromal layer, these cell lines grew rapidly, doubling every 14-23 h, to a very high density, approaching 10(7) cells/ml.
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