Posterior STEMI presenting as painless, isolated left arm numbness and weakness: a case report.

This case describes an atypical presentation of isolated posterior ST-segment elevation myocardial infarction (STEMI), who presented with left arm numbness and weakness, mimicking an acute stroke. Diagnosis was confirmed with coronary angiogram showing occlusion in proximal left circumflex artery, as well as rise in troponin. This atypical presentation highlights the importance of maintaining high index of suspicion and casting a wide net of differential diagnoses in initial assessment of patient in the emergency department.

Fostering Global Research Collaborations: An Update on Duke-NUS Medical School, the Duke University and National University of Singapore Partnership.

Problem: Navigating the complexities of international research collaborations is a challenge. This article provides a detailed examination of the international collaboration between Duke University and the National University of Singapore to establish the Duke-NUS Medical School. It explores the evolution and impact of the partnership, focusing on outcomes, knowledge advancement, and the dynamics of international collaborations in academic medicine.

Characteristics, Therapeutic Approaches and Outcomes of Patients Older than 80 Years Old with Metastatic Colorectal Cancer Compared with Younger Patients.

While advances in therapies have improved metastatic cancer survival rates, elderly patients with colorectal cancer often experience delayed diagnoses, receive less frequent systemic therapies, and show inferior survival outcomes compared to younger groups. Patients over the age of 80 years old face greater treatment risks due to frailty and comorbidities. In this article, we examine characteristics, treatment and outcomes in older adults with metastatic colorectal cancer.

Oedema as a prognostic factor for seizures in meningioma - a systematic review and meta-analysis.

Meningiomas are benign intracranial tumours that commonly lead to seizures and oedema. An understanding of seizure risk factors is essential for the meningioma community. Many studies have differing conclusions on whether oedema is associated with seizure.

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations.

Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function. As a substrate receptor of the CULLIN3-RING E3 ubiquitin ligase complex, KBTBD4 is recurrently mutated in medulloblastoma, the most common embryonal brain tumour in children. These mutations impart gain-of-function to KBTBD4 to induce aberrant degradation of the transcriptional corepressor CoREST.