Sphingosine kinase 2 (SphK2) depletion alters redox metabolism and enhances inflammation in a diet-induced MASH mouse model.

Background: Sphingosine-1 phosphate (S1P) is a bioactive lipid molecule that modulates inflammation and hepatic lipid metabolism in MASLD, which affects 1 in 3 people and increases the risk of liver fibrosis and hepatic cancer. S1P can be generated by 2 isoforms of sphingosine kinase (SphK). SphK1 is well-studied in metabolic diseases.

Opportunities and challenges for global food safety in advancing circular policies and practices in agrifood systems.

Sustainable agrifood systems are needed to provide safe and nutritious food for the growing world's population. To improve sustainability, transforming linear policies and practices in agrifood systems into circularity will be critical, with food safety considerations key for the success of this shift. This review provides a synthesis of the current and emerging risks, data gaps, and opportunities for food safety in agrifood initiatives aiming to advance circular economy models.

A case study on microlitter and chemical contaminants: Assessing biological effects in the southern coast of the Gulf of Finland (Baltic sea) using the mussel Mytilus trossulus as a bioindicator.

Chemical and microlitter (ML) pollution in three Estonian coastal areas (Baltic Sea) was investigated using mussels (Mytilus trossulus). Polycyclic aromatic hydrocarbons (PAH) in mussel tissues were observed in moderate levels with high bioaccumulation factors for the more hydrophilic and low molecular weight PAH (LMW PAH), namely anthracene and fluorene. Tissue concentrations of polybrominated diphenyl ethers (PBDE) and cadmium within mussel populations exceeded the Good Environmental Status thresholds by more than 200% and 60%, respectively.

Lightweight super-resolution multimode fiber imaging with regularized linear regression.

Super-resolution multimode fiber imaging provides the means to image samples quickly with compact and flexible setups finding many applications from biology and medicine to material science and nanolithography. Typically, fiber-based imaging systems suffer from low spatial resolution and long measurement times. State-of-the-art computational approaches can achieve fast super-resolution imaging through a multimode fiber probe but currently rely on either per-sample optimised priors or large data sets with subsequent long training and image reconstruction times.

Lung ILC2s are activated in BALB/c mice born to immunized mothers despite complete protection against respiratory syncytial virus.

Activated lung ILC2s produce large quantities of IL-5 and IL-13 that contribute to eosinophilic inflammation and mucus production following respiratory syncytial virus infection (RSV). The current understanding of ILC2 activation during RSV infection, is that ILC2s are activated by alarmins, including IL-33, released from airway epithelial cells in response to viral-mediated damage. Thus, high levels of RSV neutralizing maternal antibody generated from maternal immunization would be expected to reduce IL-33 production and mitigate ILC2 activation.