Publications by authors named "M Linggodigdo"
Unveiling the interplay of YAP1-driven pathways and miR-340-5P expression: insights into nasopharyngeal cancer metastasis.
Eur Rev Med Pharmacol Sci
November 2024
Article Synopsis
- - This study examines the expression levels of Yes-associated protein (YAP1) and miR-340-5p in nasopharyngeal carcinoma (NPC) tissues, finding that both markers are significantly lower in metastatic cases compared to non-metastatic cases.
- - Analysis of NPC samples showed that YAP1 and miR-340-5p expression decreases with cancer progression, especially in advanced stages, and that these markers may be linked through the Hippo signaling pathway.
- - The findings suggest that YAP1 and miR-340-5p could function as tumor suppressors in NPC, highlighting their potential importance in cancer research and therapy development.
Objective: To investigate the relationship between Yes-Associated Protein (YAP) and Vascular Endothelial Growth Factor-A (VEGF-A) in nasopharyngeal carcinoma (NPC) and evaluate their potential as predictive biomarkers for distant metastasis.
Methods: This observational analytic study was conducted from May to August 2023, including 60 NPC cases diagnosed histopathologically at the Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital. The study involved 30 NPC cases with distant metastasis and 30 without distant metastasis.