Publications by authors named "M Linecker"
In Germany, organ allocation is based on the MELD-system and lab-MELD is usually low in patients with hepatocellular carcinoma (HCC) in cirrhosis. Higher medical urgency can be achieved by standard exception for HCC (SE-HCC), if Milan criteria (MC) are met. Noteworthy, UNOS T2 reflects MC, but excludes singular lesions < 2 cm.
View Article and Find Full Text PDFBackground And Aims: Alterations in liver histology influence the liver's capacity to regenerate, but the relevance of each of the different changes in rapid liver growth induction is unknown. This study aimed to analyze the influence of the degree of histological alterations during the first and second stages on the ability of the liver to regenerate.
Methods: This cohort study included data obtained from the International ALPPS Registry between November 2011 and October 2020.
Objective: The aim of this study was to assess the impact of postoperative hypophosphatemia on liver regeneration after major liver surgery in the scenario of Associating Liver Partition with Portal vein ligation for Staged hepatectomy (ALPPS) and living liver donation (LLD).
Background: Hypophosphatemia has been described to reflect the metabolic demands of regenerating hepatocytes. Both ALPPS and LLD are characterized by an exceptionally strong liver regeneration and may be of particular interest in the context of posthepatectomy hypophosphatemia.
Article Synopsis
- Surgical liver failure (SLF) can occur after surgeries where too much liver tissue is removed, often leading to high mortality rates, but its causes are not well understood.
- Researchers used mouse models of different liver surgeries to investigate the effects of blood flow and oxygen levels on SLF, finding that early hypoxia contributes to the problem.
- They discovered that boosting lipid oxidation through treatments like L-carnitine can improve liver regeneration and survival rates in both mice and patients, suggesting that enhancing lipid oxidation could be a promising strategy to mitigate SLF risks in clinical settings.
Introduction: Obesity is frequently associated with its hepatic manifestation, the nonalcoholic fatty liver disease (NAFLD). The most effective treatment for morbid obesity is bariatric surgery (BS) also improving NAFLD and liver function. In patients where NAFLD has already progressed to liver cirrhosis, BS can be considered a high-risk procedure.
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