Publications by authors named "M Lilley"
This paper describes the types of social comparison used by Hispanic students at a Hispanic Majority Institution through two studies ( = 406). We found that students engaged in upward identification more often than downward identification, downward contrast, and upward contrast. However, when comparing themselves on an academic measure, downward identification and upward contrast became relatively more frequent.
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- Genetic variation in the TMEM106B gene is linked to the risk and progression of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), with a specific genotype (rs3173615) associated with longer survival after symptoms begin.
- Research shows that the protective genotype is linked to lower accumulation of TMEM106B filaments, while the risk allele correlates with increased TMEM106B core deposition and enhanced TDP-43 dysfunction.
- The findings indicate that managing the accumulation of TMEM106B filaments may be a crucial factor in reducing disease risk and slowing down the progression of FTLD-TDP.
Aducanumab, an anti-amyloid immunotherapy for Alzheimer's disease, efficiently reduces Aβ, though its plaque clearance mechanisms, long-term effects, and effects of discontinuation are not fully understood. We assessed the effect of aducanumab treatment and withdrawal on Aβ, neuritic dystrophy, astrocytes, and microglia in the APP/PS1 amyloid mouse model. We found that reductions in amyloid and neuritic dystrophy during acute treatment were accompanied by microglial and astrocytic activation, and microglial recruitment to plaques and adoption of an aducanumab-specific pro-phagocytic and pro-degradation transcriptomic signature, indicating a role for microglia in aducanumab-mediated Aβ clearance.
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