A Unique Case of MBD5 and CCM2 Deletions Leading to a Severe Neurological Phenotype With Prolonged Status Epilepticus.

Heterozygous pathogenic variants in MBD5 (MIM*611472) and CCM2 (MIM*607929) cause autosomal dominant intellectual developmental disorder 1 (MIM#156200) and cerebral cavernous malformations-2 (MIM#603284), respectively. Both conditions may present with seizures, epilepsy, and status epilepticus. However, super-refractory status epilepticus, defined as seizures lasting more than 24 h, has not been described in either condition.

[Consensus Recommendations for Lung Cancer Screening in Chile].

Unlabelled: Lung cancer is the leading cause of cancer death worldwide, also in Chile, where the main risk factor is smoking. Early detection using low-dose computed tomography has been shown to reduce mortality from this cause, but there are still no formal screening recommendations in Chile.

Aim: This initiative aimed to develop recommendations for lung cancer screening in Chile through an expert consensus process.

Comparison of in vitro cell survival predictions using Monte Carlo methods for proton irradiation.

Purpose: It is possible to combine theoretical models with Monte Carlo simulations to investigate the relationship between radiation-induced initial DNA damage and cell survival. Several combinations of models have been proposed in recent years, sparking interest in comparing their predictions in view of future clinical applications.

Methods: Two in silico methods for calculating cell survival fractions were optimized for proton irradiation of the Chinese hamster V79 cell line, for LET values ranging from 3.

[Use of standardized criteria to verify interruption of a measles outbreak in the Buenos Aires Metropolitan Area during the COVID-19 pandemicEncerramento do surto de sarampo na área metropolitana de Buenos Aires durante a pandemia de COVID-19 aplicando critérios padronizados].

Objective: To describe the strategy implemented for interruption of the 2019-2020 measles outbreak in the Metropolitan Area of Buenos Aires (Argentina) and application of the Pan American Health Organization (PAHO) standardized outbreak closure criteria to verify interruption of viral circulation in an adverse setting (the COVID-19 pandemic).

Methods: Descriptive, retrospective observational study of the actions taken in response to the measles outbreak that occurred between epidemiological week (EW) 35 of 2019 and EW 12 of 2020. Interruption of viral circulation was documented through epidemiological, vaccination-coverage, and laboratory criteria.

High-Performance Concrete from Rubber and Shell Waste Materials: Experimental and Computational Analysis.

Waste and its environmental impact have driven the search for sustainable solutions across various industries, including construction. This study explores the incorporation of solid waste in the production of eco-friendly structural concrete, aiming to reduce pollution and promote ecological and sustainable construction practices. In this context, two types of eco-friendly concrete were produced using marine shells and recycled rubber as waste materials and compared with conventional concrete through experimental and computational approaches.