Publications by authors named "M Librizzi"
Article Synopsis
- * A study involving 49 patients with pituitary apoplexy showed that while many experienced improvement in vision and eye movement after surgery, the timing of surgery (within 3 days vs. later) did not significantly affect these outcomes.
- * Overall, the results indicate that the timing of neurosurgical decompression for pituitary apoplexy patients may not play a crucial role in improving their visual symptoms.
Purpose: To identify clinical and radiological factors associated with a higher risk of developing a severe pituitary apoplexy (PA).
Methods: Multicenter retrospective study of patients presenting with clinical PA in three Spanish tertiary hospitals of Madrid between 2008 and 2022. We classified PA as severe when presenting with an altered level of consciousness (Glasgow Coma Scale (GCS) < 15) or visual involvement.
Article Synopsis
- * Marine biodiversity offers a rich source of unique natural products that can be utilized in medicine, particularly for their potential anticancer, anti-inflammatory, and regenerative properties.
- * The review aims to compile studies on the isolation of peptides from marine animals and their demonstrated anticancer effects in laboratory settings, organized by the taxonomy of the source organisms.
Autophagy is an evolutionarily conserved process critical in maintaining cellular homeostasis. Recently, the anticancer potential of autophagy inducers, including phytochemicals, was suggested. Indicaxanthin is a betalain pigment found in prickly pear fruit with antiproliferative and pro-apoptotic activities in colorectal cancer cells associated with epigenetic changes in selected methylation-silenced oncosuppressor genes.
View Article and Find Full Text PDFParathyroid-hormone-related protein (PTHrP) is encoded by the gene which, via alternative promoter usage and splicing mechanisms, can give rise to at least three isoforms of 139, 141, and 173 amino acids with distinct C-terminals. PTHrP is subjected to different post-translational processing that generates smaller bioactive forms, comprising amino terminus, mid-region (containing a nuclear/nucleolar targeting signal), and carboxy terminus peptides. Both the full-length protein and the discrete peptides are key controllers of viability, proliferation, differentiation, and apoptosis in diverse normal and pathological biological systems via the reprogramming of gene expression and remodulation of PKA or PKC-mediated signalization mechanisms.
View Article and Find Full Text PDF