Publications by authors named "M Lezinger"
Article Synopsis
- Drug-resistant epilepsy (DRE) significantly impacts the lives of children and young adults, prompting a study on the effectiveness and safety of purified CBD for this population.
- The study analyzed data from 139 patients, revealing that a significant majority experienced reduced seizure frequency after treatment, with 41.1% showing over a 50% reduction, along with improvements in alertness and speech.
- While purified CBD proved to be well-tolerated and effective, common side effects included irritability and drowsiness, with previous treatments influencing the likelihood of seizure reduction.
This study aimed to investigate the efficacy and tolerability of Lacosamide (LCM) in a pediatric population with epilepsy using LCM serum concentration and its correlation to the age of the participants and the dosage of the drug. Demographic and clinical data were collected from the medical records of children with epilepsy treated with LCM at Shamir Medical Center between February 2019 to September 2021, in whom medication blood levels were measured. Trough serum LCM concentration was measured in the biochemical laboratory using High-Performance Liquid Chromatography (HPLC) and correlated with the administered weight-based medication dosing and clinical report.
View Article and Find Full Text PDFBackground: The notion that pediatric type 1 diabetes impacts brain function and structure early in life is of great concern. Neurological manifestations, including neurocognitive and behavioral symptoms, may be present from childhood, initially mild and undetectable in daily life. Despite intensive management and technological therapeutic interventions, most pediatric patients do not achieve glycemic control targets for HbA1c.
View Article and Find Full Text PDFAutistic Spectrum Disorder (ASD) is a common neurodevelopmental disorder and no effective treatment for the core symptoms is currently available. The present study is part of a larger clinical trial assessing the effects of cannabis oil on autism co-morbidities. The aim of the present study was to assess the safety of a CBD-rich oil treatment in children and adolescents with ASD.
View Article and Find Full Text PDFObjective: To assess the association between hyperglycemia and electrical brain activity in type 1 diabetes mellitus (T1DM).
Methods: Nine youths with T1DM were monitored simultaneously and continuously by EEG and continuous glucose monitor system, for 40 h. EEG powers of 0.