On the concordance between electrical source imaging, anatomical and functional neuroimaging in patients with focal epilepsy.

Objective: Limited knowledge exists regarding how electrical source imaging (ESI) of interictal epileptiform discharges (IEDs) aligns with findings from other neuroimaging modalities. This study investigates the relationships of interictal ESI with MRI, 18FDG PET, SISCOM, and voxel-based morphometry (VBM) during presurgical evaluation of drug-resistant epilepsy (DRE).

Methods: A cross-sectional study evaluated the concordance of IED locations from ESI using various inverse solutions (CLARA, LAURA, LORETA, SLORETA, SWLORETA, SSLOFO) with MRI lesions, 18FDG PET, SISCOM, and VBM grey matter abnormalities.

The Omics-Driven Machine Learning Path to Cost-Effective Precision Medicine in Chronic Kidney Disease.

Chronic kidney disease (CKD) poses a significant and growing global health challenge, making early detection and slowing disease progression essential for improving patient outcomes. Traditional diagnostic methods such as glomerular filtration rate and proteinuria are insufficient to capture the complexity of CKD. In contrast, omics technologies have shed light on the molecular mechanisms of CKD, helping to identify biomarkers for disease assessment and management.

Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease.

Naturally occurring fragments of collagen type I alpha 1 chain (COL1A1) have been previously associated with chronic kidney disease (CKD), with some fragments showing positive and others negative associations. Using urinary peptidome data from healthy individuals (n = 1131) and CKD patients (n = 5585) this aspect was investigated in detail. Based on the hypothesis that many collagen peptides are derived not from the full, mature collagen molecule, but from (larger) collagen degradation products, relationships between COL1A1 peptides containing identical sequences were investigated, with the smaller (offspring) peptide being a possible degradation product of the larger (parent) one.

Bioorthogonal Monomycolate of Trehalose Disclosed the -Mycoloylation of Mycoloyltransferases and Other Cell Envelope Proteins in .

Protein mycoloylation is a recently identified unusual post-translational modification (PTM) exclusively observed in Mycobacteriales, an order of bacteria that includes several human pathogens. These bacteria possess a distinctive outer membrane, known as the mycomembrane, composed of very long-chain fatty acids called mycolic acids. It has been demonstrated that a few mycomembrane proteins undergo covalent modification with mycolic acids in the model organism through the action of mycoloyltransferase MytC.