Publications by authors named "M Leverone"

Article Synopsis
  • The study focuses on two patients with atypical progeroid syndrome and partial lipodystrophy caused by a mutation in the LMNA gene, examining how their underlying cardiovascular issues worsened after mild COVID-19.
  • Both patients had pre-existing cardiovascular conditions alongside other risk factors, which were significantly aggravated by SARS-CoV-2 infection, leading to severe complications.
  • The findings highlight that patients with LMNA mutations should be monitored closely for potential cardiac issues after COVID-19, emphasizing the importance of vaccination for those with lipodystrophy and comorbidities.
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In this report, we present the case of a previously healthy 80-year-old woman who was referred to surgery after a cardiac arrest due to ventricular fibrillation successfully resuscitated; the following evaluation revealed acute mitral regurgitation due to chordae tendineae rupture. After mitral valve repair, a single-chamber cardioverter-defibrillator was implanted for secondary prevention of sudden cardiac death. After 16 months of follow-up, the patient is asymptomatic without any further episodes of ventricular arrhythmias reported, underlying the pivotal role of mitral valve repair in the prevention of potentially lethal ventricular arrhythmias.

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The development of an aortic pseudoaneurysm of the ascending aorta is described as a potential complication after composite graft surgery for combined disorders that simultaneously affect the aortic valve and ascending aorta; in the literature it has been reported to range from 7 to 25%. The aorta-right atrial fistula is an infrequent complication of aortic dissection and it is rarely diagnosed in association with aortic pseudoaneurysm. The pathophysiological mechanism of the first seems to be related to dehiscence of the suture line at the anastomosis site; in the second to anatomic contiguity between the aorta and right atrium.

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