Publications by authors named "M Lesosky"

Background: The goal of post-diagnosis diabetes management is the achievement and maintenance of glycaemic control. Most clinical practice guidelines recommend 3-6 monthly HbA1c monitoring. Despite this guidance, there are few data supporting the impact of monitoring frequency on clinical outcomes, particularly from low- and middle-income country settings.

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Background: In western Kenya, a cluster-randomized trial is assessing the impact of attractive targeted sugar baits (ATSBs) on malaria in children enrolled in three consecutive cohorts. Here, characteristics of children and households at enrolment, and factors associated with baseline malaria prevalence are described.

Methods: Children aged 1 to < 15 years were randomly selected by cluster (n = 70) from a census database.

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Article Synopsis
  • High resistance to sulfadoxine-pyrimethamine is jeopardizing its effectiveness in preventing malaria in pregnant women, prompting the exploration of dihydroartemisinin-piperaquine as a new treatment alternative in Western Kenya.
  • A trial was conducted in 18 antenatal clinics to compare adherence and delivery effectiveness of this new multiday treatment regimen against the standard single-dose treatment, involving random assignment to three different study groups.
  • The main focus was to measure adherence by checking how many participants successfully completed the 3-day dihydroartemisinin-piperaquine regimen, verified through home visits and pill counts.
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Background: Silicosis, a chronic respiratory disease caused by crystalline silica exposure, is a persistent global lung health issue. No systematic review of the relationship between cumulative respirable crystalline silica (RCS) exposure and silicosis exists. UK exposure limits are currently under review.

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Type 2 diabetes (T2D) represents a growing disease burden in South Africa. While glycated haemoglobin (HbA1c) testing is the gold standard for long-term blood glucose management, recommendations for HbA1c monitoring frequency are based on expert opinion. This study investigates the effectiveness and cost-effectiveness of alternative HbA1c monitoring intervals in the management of T2D.

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