[Granulomatous lung disease induced by kayexalate inhalation during immunotherapy for metastatic melanoma].

Introduction: When a patient treated by immune checkpoint inhibitors for metastatic melanoma presents with pulmonary symptoms, several diagnoses are possible. We report a case of acute granulomatous lung disease secondary to repeated kayexalate inhalations, and probably stimulated by immunotherapy.

Case Report: A patient treated with pembrolizumab and then ipilimumab presented with fever and acute shortness of breath.

[Use of rituximab in maintenance treatment of pemphigus: A retrospective series].

Introduction: Rituximab (RTX), currently recommended as first-line treatment in moderate to severe pemphigus vulgaris (PV) and superficial pemphigus (PS) along with initial systemic steroids, may also be used as second-line or subsequent treatment, and this therapeutic strategy was investigated in a real-life monocentre retrospective survey.

Material And Methods: All patients treated between January 2010 and March 2018 with RTX as second-line or subsequent treatment for moderate to severe PV or PS and followed for at least one year were included. The main objective was to evaluate rates and times of complete clinical remission (CCR) after a first course of RTX.