Publications by authors named "M Leptin"
The initially homogeneous epithelium of the early embryo differentiates into regional subpopulations with different behaviours and physical properties that are needed for morphogenesis. The factors at top of the genetic hierarchy that control these behaviours are known, but many of their targets are not. To understand how proteins work together to mediate differential cellular activities, we studied in an unbiased manner the proteomes and phosphoproteomes of the three main cell populations along the dorso-ventral axis during gastrulation using mutant embryos that represent the different populations.
View Article and Find Full Text PDFCopy number variation in large gene families is well characterized for plant resistance genes, but similar studies are rare in animals. The zebrafish () has hundreds of NLR immune genes, making this species ideal for studying this phenomenon. By sequencing 93 zebrafish from multiple wild and laboratory populations, we identified a total of 1513 NLRs, many more than the previously known 400.
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Article Synopsis
- The inflammasome is a special structure inside cells that helps detect danger and can cause cell death when it's activated.
- Scientists created a new version of a protein called ASC that can be controlled with light, making it easier to study how the inflammasome works in living creatures.
- They tested this in zebrafish and found that the way cells die using this method is different depending on the type of skin cell, which can affect how they interact with nearby cells.
Article Synopsis
- Brillouin microscopy offers a non-contact way to study the mechanical properties of biological samples in 3D, but its weak signals can result in long imaging times and harmful light exposure for living organisms.
- This study introduces a high-resolution line-scanning Brillouin microscope that allows for quicker imaging of dynamic biological processes while minimizing phototoxic effects.
- By enhancing background suppression and combining it with fluorescence light-sheet imaging, researchers can effectively visualize the mechanical properties of cells and tissues in living models like fruit flies, ascidians, and mouse embryos.