Publications by authors named "M Lepoivre"
Article Synopsis
- Acute myeloid leukaemia (AML) is a complex cancer marked by various genetic abnormalities and a heightened oxidative stress environment, making it a target for redox-based therapies.
- Research has shown that the combination of auranofin (AUF), a drug initially used for rheumatoid arthritis, and vitamin C (VC) effectively kills different leukemia cell lines by increasing reactive oxygen species and inhibiting protein synthesis.
- Testing on 22 primary AML samples revealed that this drug combination can effectively eliminate leukaemic cells while being less harmful to normal cells, suggesting a promising anti-AML treatment strategy.
Article Synopsis
- Iron-sulfur (Fe-S) clusters are important parts of proteins that help with many vital processes in living things, like breathing and making energy.
- These clusters can gain or lose electrons, and they are very sensitive to things like oxygen.
- Although it's tricky to find new Fe-S proteins because they can look different in various proteins, new ways to study them are helping scientists discover more about their roles.
Human mitoNEET (mNT) and CISD2 are two NEET proteins characterized by an atypical [2Fe-2S] cluster coordination involving three cysteines and one histidine. They act as redox switches with an active state linked to the oxidation of their cluster. In the present study, we show that reduced glutathione but also free thiol-containing molecules such as β-mercaptoethanol can induce a loss of the mNT cluster under aerobic conditions, while CISD2 cluster appears more resistant.
View Article and Find Full Text PDFThe NEET proteins, an important family of iron-sulfur (Fe-S) proteins, have generated a strong interest due to their involvement in diverse diseases such as cancer, diabetes, and neurodegenerative disorders. Among the human NEET proteins, CISD3 has been the least studied, and its functional role is still largely unknown. We have investigated the biochemical features of CISD3 at the atomic and in cellulo levels upon challenge with different stress conditions i.
View Article and Find Full Text PDFRedox homeostasis is an equilibrium between reducing and oxidizing reactions within cells. It is an essential, dynamic process, which allows proper cellular reactions and regulates biological responses. Unbalanced redox homeostasis is the hallmark of many diseases, including cancer or inflammatory responses, and can eventually lead to cell death.
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