Publications by authors named "M Lepilin"
Cardiosphere-derived cells (CDCs) are currently being evaluated in clinical trials as a potential therapeutic tool for regenerative medicine. The effectiveness of transplanted CDCs is largely attributed to their ability to release beneficial soluble factors to enhance therapeutic effects. An emerging area of research is the pretreatment of stem cells, including CDCs, with various cytokines to improve their therapeutic properties.
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- Ischemic heart disease is a leading cause of death, with the adult heart lacking natural regenerative abilities after damage.
- Stem-cell-based therapies, particularly cardiosphere-derived cells (CDCs), show promise for treating heart damage due to their ability to secrete bioactive molecules that promote healing.
- Research indicates that Tumor Necrosis Factor alpha (TNFa), present in the inflammatory environment of damaged heart tissue, can enhance the secretome of CDCs, potentially improving their ability to support new blood vessel formation.
Purpose: to assess rate of complications after transcatheter aortic valve implantation (TAVI).
Material And Results: Our study included 99 patients who underwent TAVI. Frequent complications were: bleeding not requiring surgical hemostasis (17.
[DEXMEDETOMIDINE SEDATION DURING TRANSCATHETER AORTIC VALVE IMPLANTATION.].
Anesteziol Reanimatol
July 2016
The Aim: to determine the efficacy and safety of dexmedetomidinefor sedation and analgesia during transcatheter aortic valve implantation (TA VI) withfemoral access.
Materials And Methods: the study included 34 high-risk surgical patients with "critical aortic stenosis". All patients underwent TAVI with femoral access.
Purpose: To find an advisability of use of invasive monitoring of intracardiac haemodynamics during transfemoral transcatheter aortic valve replacement.
Patients And Methods: The study included 12 patients underwent transfemoral transcatheter aortic valve replacement (TTAVR). All patients were monitored according to Harvard standard.